Re-evaluating sarcoplasmic reticulum function in heart failure
نویسندگان
چکیده
منابع مشابه
Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure
Heart function vitally relies on precisely controlled intracellular Ca homeostasis during each cardiac cycle. Abnormalities in Ca regulation cause contractile dysfunction and arrhythmias under different pathological conditions including heart failure (HF). Playing a particularly important role in heart contraction is the sarcoplasmic reticulum (SR). In adult ventricular myocytes, the SR forms a...
متن کاملCalcium sequestration by the sarcoplasmic reticulum in heart failure.
Myocardial contraction and relaxation are dependent w 2qx upon the rise and fall of cytosolic Ca in cardiac myocytes. The release and sequestration of Ca by the sarcoplasmic reticulum are the principal mechanisms through which this occurs. During relaxation, Ca is actively transported from the cytosol into the sarcoplasmic reticulum; during contraction, this sequestered Ca is passively released...
متن کاملSarcoplasmic reticulum in heart failure: central player or bystander?
Ronald M. Phillips , Prakash Narayan , Ana M. Gomez , Keith Dilly , Larry R. Jones , ́ W. Jonathan Lederer , Ruth A. Altschuld a,) a Department of Medical Biochemistry, Ohio State UniÕersity Medical Center, 333 Hamilton Hall, 1645 Neil AÕenue, Columbus, OH 43210-1218, USA b Departments of Molecular Biology and Biophysics and Physiology, UniÕersity of Maryland School of Medicine, Baltimore, MD 21...
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WOOD, AND ARNOLD SCHWARTZ. Mitochondria and sarcoplasmic reticulum function in cardA hypertrophy and failure. Am. J. Physiol. 224(3) : 497-502. 1973.-Mitochondria and “sarcoplasmic reticulum” cardiac relaxing system (CRS) were isolated from rabbit hearts that were in various stages of hypertrophy and failure induced by progressive stenosis of the ascending aorta. The latter was produced by Amer...
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T his article reflects on the impact of a classic paper identifying the effects of loss of sarcoplasmic reticu-lum Ca-ATPase activity in heart failure. Understanding the effects of heart failure on contraction and Ca signaling in the heart has long been a priority. By the late 1980s, many studies on animal models had shown that heart failure resulted in a slowing of the decay of the systolic Ca...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2000
ISSN: 1078-8956,1546-170X
DOI: 10.1038/79592